Recent advances in mucosal immunity

Recent advances in understanding antitumor immunity

The term "antitumor immunity" refers to innate and adaptive immune responses which lead to tumor control. Turning the immune system into a destructive force against tumors has been achieved in a broad range of human cancers with the use of non-specific immunotherapies, vaccines, adoptive-cell therapy, and, more recently with significant success, through blockade of immune checkpoints. Neverthel...

Recent Advances in Hemophilia Gene Therapy

Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...

Recent Advances in Mucosal Immunology and Ocular Surface Diseases

Recent advances in the role of immunity in atherosclerosis.

T he immune system serves to protect the host from a diverse array of pathogens that evolve rapidly in an effort to breach immune security checkpoints. These defense mechanisms operate continuously to keep exogenous pathogens from propagating their own species, although this heightened security has unintended and detrimental consequences to the host. 1 Although this maladaptive immune response ...

Recent Advances In Treatment of Acute Organophosphorous Nerve Agents Poisoning

Organophosphorous (OP) chemical warfare nerve agents mainly sarin and tabun were used during the Iran-Iraq war with high mortalities. In addition to atropine and oximes, the followings have recently been used successfully for the treatment of OP poisoning. 1. Sodium Bicarbonate: Infusion of high doses of sodium bicarbonate (5 mEq/kg in 60 min. followed by 5-6 mEq/kg/day to obtain arterial blood...